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Fat and fertility are linked in women, through leptin. Low leptin levels reduce fertility.

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Ovarian function of adult women is associated with their fatness at birth. In our evolutionary past food insecurity was a frequent occurrence.

Women would have benefited from an increased ability to store fat in easily metabolisable depots. We suggest that the pattern of central obesity, more commonly seen in men, is not adaptive, but rather reflects the genetic drift hypothesis of human susceptibility to obesity. Female obesity, with excess adiposity in the lower extremities, reflects an exaggeration of an adaptation for female reproductive success.

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Abstract Human beings are susceptible to sustained weight gain in the modern environment. Publication types Research Support, N. Background: Hypothalamic dysfunction occurs early in the clinical course of Alzheimer's disease A likely contributing to disturbances in feeding behavior and metabolic function that are often observed years prior to the onset of cognitive symptoms.

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Late-life weight loss and low BMI are associated with increased risk of dementia and faster progression of disease. However, high-fat diet and metabolic disease e.

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Considering the sex bias in AD, with women representing two-thirds of AD patients, we sought to determine whether these relationships vary by sex. Results: On control diet, male 3xTg-AD mice displayed decreased body weight, reduced fat mass, hypoleptinemia, and mild systemic inflammation, as well as increased expression of gliosis- and inflammation-related genes in the hypothalamus Iba1, GFAP, TNF-?, IL-1?.

Considering the sex bias in AD, with women representing two-thirds of AD patients, we sought to determine whether these relationships vary by sex. Methods: WT and 3xTg-AD male and female mice were fed a control (10fat) or high-fat (HF 60fat) diet from months of age, then tested for metabolic and hypothalamic disturbances Browse 9, fat teen stock photos and images available or search for chubby boy or chubby teen to find more great stock photos and pictures. authentic group of diverse friends having fun - fat teen stock pictures, royalty-free photos & images. unhealthy eating - fat teen stock pictures, royalty-free photos & images. portrait of a beautiful african american woman - fat teen stock pictures, royalty-free photos & 03/01/  Studies have shown that by losing between 5 and 10 percent of your body weight, you can get rid of 25 to 40 percent of your hard fat. A combination of diet and exercise is the obvious way to lose

In contrast, female 3xTg-AD mice on control diet displayed metabolic disturbances opposite that of 3xTg-AD males increased body and fat mass, impaired glucose tolerance.



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